Paraaminobenzoic acid or vitamin B10, H1, PABA, RABA is a vitamin-like compound derived from benzoic acid, which has a powerful antioxidant effect on the human body.
The name of the substance comes from two words - "pan" - everywhere, "gami" - a seed, which indicates the widespread distribution of the nutrient in nature, for example in the seeds of plants.
The compound stimulates the growth of lacto - and bifidobacteria, has antiviral properties, and is used for the manufacture of novocaine. Bacterial vitamin H1 protects the skin from the harmful effects of sunlight, improves the condition of the hair, so manufacturers add to the composition of conditioners, body creams, shampoos, ointments against burns, suntan lotions, conditioners.
4-Aminobenzoic acid is a white powder, has a crystalline structure, is highly soluble in alcohol, ether, poorly in water. PABA is resistant to high temperatures, does not collapse upon boiling (melting point reaches 187 degrees), and is sensitive to light.
The structural formula of the compound is C7H7NO2.
The Importance and Need of Vitamin B10
Consider why the body needs H1.
- Prevents premature aging, wrinkles.
- Participates in the exchange of proteins (DNA and RNA), the synthesis of pyrimidines, purines, and the production of melanin.
- Promotes the growth of muscle tissue.
- Provides normal digestion.
- Strengthens the immune system, stimulates the synthesis of interferon, increasing the body's resistance to infectious agents.
- Protects the liver from cirrhosis.
- It is necessary to replace the structures of cells, tissues, maintain the health of men (prevents the appearance of Peyronie's disease).
- It normalizes fat metabolism, cholesterol in the blood, preventing the appearance of atherosclerosis.
- Prevents a hangover.
- It improves blood formation (supplies blood with oxygen, participates in the production of red blood cells), reduces the risk of anemia, blood clots, and strokes.
- It protects the skin from UV rays, increases its tone and elasticity, eliminates pigmentation, ensures the formation of an even tan.
- Prevents hair loss, maintains its natural color, protects against early graying.
- Improves tissue repair after injuries, growth in children, adolescents, the production of human milk during lactation and thyroid hormones.
- Stimulates the reproduction of beneficial microflora in the intestine.
In addition, para-aminobenzoic acid increases the effectiveness of B vitamins (B5, B9), C.
Instructions for use
Given the fact that PABA has not been studied much to date, according to published data, the human need for compound is 100 milligrams per day. For medicinal purposes, the dosage of vitamin H1 is determined by the attending physician, depending on the type of therapy and the nature of the disease.
Vitamin supplements are recommended to be consumed after a meal with 100 milliliters of still water.
Causes and signs of insufficiency, excess PABA
Vitamin B10 deficiency is rare because the compound is widespread in nature and found in many foods (see p. Sources of para-aminobenzoic acid).
Most often, PABA deficiency occurs against the background of prolonged use of antibiotics, analgesics, antipyretic drugs, estrogen-like drugs, or sulfonamides. In addition, improper storage and preparation of foods rich in vitamin h1 leads to a loss of healthy nutrition. Para-aminobenzoic acid is destroyed under the prolonged influence of high temperatures (over 20 minutes), the action of water, alcohol.
Signs of a deficiency of para-aminobenzoic acid:
- disorders of the hormonal background, the work of the gastrointestinal tract, nervous system;
- developmental delay, growth;
- hair loss, brittle hair (baldness);
- frequent sunburn;
- the appearance of rashes, age spots, dermatological diseases;
- lack of milk in nursing women.
Characteristic signs of excess vitamin H1 in the body:
- suppression of the thyroid gland.
An excess of para-aminobenzoic acid in the body does not pose a threat to human life. Symptoms of an overdose go away after a decrease in the amount of substance taken.
Indications and contraindications
Vitamin B10 is used in medicine to eliminate the following painful conditions:
- neuro - emotional stress;
- arthritis and arthrosis;
- vitiligo disease;
- physical, mental overwork;
- anemia (folic acid deficiency);
- Dupuytren's contracture;
- diseases of the skin, in particular itchy dermatoses;
- Peyronie's disease;
- delays in development, growth;
- eye diseases;
- fragility of nails;
- ultraviolet burns;
- bronchial asthma;
- chronic coronary insufficiency;
- hepatitis A;
- cerebral sclerosis;
- cirrhosis of the liver at the initial stage;
- chronic alcohol intoxication;
- bronchial asthma.
In addition, para-aminobenzoic acid is used to strengthen hair, better tolerance of corticosteroids, sulfonamides, anti-tuberculosis drugs.
Contraindications for taking PABA include:
- disorders of the thyroid gland;
- sensitivity to the drug.
In 90% of cases, vitamin b10 is well absorbed by the body, with sufficient intake of folic acid, without causing adverse reactions.
In a healthy person (without problems with the gastrointestinal tract) with a balanced diet, compound H1 is synthesized by intestinal microflora.
PABA absorption occurs in the upper intestine. At the same time, part of the compound is used by the microflora of the large intestine to synthesize vitamin B9. The concentration of para-aminobenzoic acid in human blood is from 2 to 70 micrograms per deciliter.
The compound is excreted in the urine in acetylated form. The level of PABA in the body depends on the state of human health: with peptic ulcer, chronic hepatitis, cholecystitis, Botkin’s disease, it decreases, in the presence of problems with the cardiovascular system it increases. With feces, 250 micrograms of nutrient is excreted.
Sources of para-aminobenzoic acid
Vitamin B10 was first isolated from yeast and subsequently found in foods. At the same time, food coloring, refined sugar reduce the production of PABA by intestinal microflora.
Consider where the substance is contained and in what quantity (data are presented based on x microgram of nutrient per 100 grams of product):
- dry brewer's yeast - 5.7;
- liver (beef, pork) - 0.25;
- kidneys - 0.18;
- heart, brains - 0.135;
- mushrooms - 0.13;
- spinach - 0.06;
- wheat - 0.06;
- chicken eggs - 0.04;
- potatoes - 0.036;
- carrots - 0.022;
- white cabbage - 0.02;
- Cow's milk - 0.01.
Food sources containing small amounts of vitamin H1 (up to 0.01 micrograms of substance per 100 grams of product):
- rice bran;
- sunflower seeds;
- dairy products (kefir, cottage cheese, cheese);
- nuts (cashews, hazelnuts, pistachios, walnuts);
- oat groats;
- a fish;
- pumpkin seeds, sesame seeds;
- kernels of apricot kernels.
In the absence of digestive tract diseases and a balanced diet, the constant presence in the daily menu of plant / animal products rich in para-aminobenzoic acid excludes the body's need for additional intake of a vitamin compound with drugs and additives.
However, the presence of diseases of the liver and stomach impairs the absorption of nutrients from the gastrointestinal tract and is a "signal" to receive synthetic B10.
Interaction with other substances
In medical practice, vitamin H1 has not been widely used, despite the fact that experimentally and in the clinic the compound was used for prophylactic, therapeutic purposes to eliminate a number of skin diseases. The use of PABA in large doses (5 grams per day) in the complex treatment of typhus, showed the high effectiveness of the drug. In the treatment of rickettsioses with para-aminobenzoic acid, relative to conventional therapeutic measures, the mortality rate from this disease decreased by 3 times, and the healing process accelerated.
Vitamin B10 in a dose of 0.1 to 0.5 grams is used to treat hypertension, atherosclerosis. After a course of therapy of 20 days, the patients increased working capacity, improved overall health, normalized protein, lipid metabolism.
Consider how para-aminobenzoic acid affects the absorption of other substances and vice versa.
- Alcohol, penicillin, sulfa drugs, sugar destroy vitamin B10 in the human body.
- The combined effect of folic, paraaminobenzoic acid and pyridoxine inhibits graying of hair.
- B10 reduces the effectiveness of thyroid hormones, the effects of adrenaline.
- Para-aminobenzoic acid reduces the side effects of excess aspirin in the body.
- Compound H1 increases the effectiveness of vitamins C, B5, B9.
- Vitamins A, E enhance the effect of the nutrient on the metabolism.
- PABA reduces the activity of thyroid hormones.
Vitamin H1 is available in tablets, drops, powders, capsules, vials and ampoules (as a solution for injection and eye instillation). The most popular PABA preparation is RABA, which is produced by Now Foods, an American corporation. In addition, para-aminobenzoic acid is part of the multivitamin complexes - Multivita, Vitrum.